Treatment of cyclosporin-induced gingival hyperplasia with azithromycin.
نویسندگان
چکیده
BACKGROUND Gingival hyperplasia is a known complication of cyclosporin therapy. Although plaque control has been shown to be of benefit, gingival surgery is occasionally necessary. The aim of this study was to review the effect of a short-course therapy with azithromycin in renal transplant patients with cyclosporin-induced gingival hyperplasia. METHODS Thirty-eight patients received 500 mg/day of azithromycin for 3 consecutive days. The degree of gingival hyperplasia was classified as: 0, no gingival overgrowth; 1, mild overgrowth; 2, moderate overgrowth, and 3, severe overgrowth. Gingival bleeding and evolution of gingival hyperplasia were determined at 0 (pretreatment), 7, 30, 90 and 180 days. Cyclosporin, serum creatinine and ALT levels were simultaneously determined on the same days. RESULTS Seven patients were excluded, leaving a total of 31 included in the trial. Eleven had a score of 3, 17 a score of 2, and 3 a score of 1. The degree of gingival hyperplasia was unrelated to the dose and levels of cyclosporin. Gingival hyperplasia improved in all patients (P < 0.001, Friedman test). The degree of improvement was better when the degree of hyperplasia was lower. In 27 patients gingival hyperplasia remained absent 6 months later, 3 patients required a second course of treatment, and another required gingival surgery. Gingival bleeding, present in 28 patients when diagnosed, disappeared in all cases in 2.2 +/- 1.2 (1-7) days. No adverse effects were observed. Cyclosporin, serum creatinine, and ALT levels were not affected by treatment. CONCLUSIONS Azithromycin improves cyclosporin-associated gingival hyperplasia, especially when administered early in the process.
منابع مشابه
بررسی تأثیر آزیترومایسین در درمان افزایش حجم لثه ناشی از مصرف سیکلوسپورین در بیماران پیوند کلیه
Statement of Problem: Gingival overgrowth is a side effect commonly induced by Cyclosporin treatment. The effects of Azithromycin, a macrolidic antibiotic, has been focused on gingival enlargement treatment induced by cyclosporine in numerous articles. Purpose: The goal of the present study was to survey the effects of systemic Azithromycin in the treatment of gingival overgrowth induced by cyc...
متن کاملCyclosporin A-induced gingival hyperplasia in psoriasis: review of the literature and case reports.
Cyslosporin A (CyA) treatment of psoriasis is warranted in severe cases where other, conventional antipsoriatic approaches have failed. Gingival hyperplasia is a rare side effect of cyclosporin A treatment in psoriasis patients. Previous studies in cyclosporin A-treated patients (mostly transplant recipients) have demonstrated correlation between cyclosporin A serum levels and oral hygiene stat...
متن کاملMechanism of azithromycin treatment on gingival overgrowth.
Azithromycin is effective for the remission of cyclosporine A-induced gingival overgrowth (CIGO) in persons who have undergone renal transplant. To explain its mechanism in alleviating the clinical symptoms of these individuals, we examined the effect of azithromycin on cell proliferation and collagen turnover modified by cyclosporin A in human gingival fibroblasts from healthy persons and from...
متن کاملGingival hyperplasia associated with cyclosporin A.
2466 A 45-year-old woman presented in 1992 with symmetrical polyarthritis affecting the small joints of the hands and wrists bilaterally. The diagnosis of rheumatoid arthritis (RA) was made and she was given methotrexate and small doses of prednisone, with significant improvement. In 1997 she experienced a flare of the synovitis and cyclosporin A (CSA) (3 mg/kg/day), equivalent to 200 mg/day, w...
متن کاملResolution of cyclosporine-induced gingival hyperplasia resistant to azithromycin by switching to tacrolimus.
Cyclosporine (CsA)-induced gingival hyperplasia (CIGH) is a common side effect of CsA. A 54-year old woman was diagnosed as having severe aplastic anemia with trilineage cytopenia. Since she had no HLA-matched relatives, she was treated with immunosuppression including anti-lymphocyte globulin, methylprednisolone, recombinant human granulocyte colonystimulating factor and CsA (oral dose of 3.5 ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
دوره 12 12 شماره
صفحات -
تاریخ انتشار 1997